Scientists identify a protein complex that shapes the destiny of T cells

(St. Jude Children's Research Hospital) The protein complex is mTORC1, which regulates cell growth and metabolism. St. Jude immunologists found mTORC1 acts in response to cues from in and around developing T cells and intersects with metabolic activity, to influence whether the cells become conventional or unconventional T cells. To their surprise, researchers found that disrupting mTORC1 led to metabolic changes that favored development of unconventional T cells at the expense of conventional T...